Gluten Sensitivity and autoimmune diseases

Gluten Sensitivity and Autoimmune Diseases

Autoimmune diseases like lupus, rheumatoid arthritis, multiple sclerosis, psoriasis, celiac disease, thyroid disease, are the top health concerns of the 21st century and those afflicted growing in number every year. Autoimmune diseases are responses to systemic inflammation that results in your body attacking its own tissues. Could there be a connection between food sensitivities and more notably gluten sensitivity and autoimmune diseases?

Diseases, like autoimmune diseases, are basically a group of symptoms that fit a common profile of others who suffer the same symptoms. Then it’s given a label. Having a label is fine, but it doesn’t help you with the root cause.

Food sensitivities are unlike food allergies.  Food allergies involve a histamine response to an offending food and the reaction is immediate and can be life-threatening for those with severe allergies. Food sensitivities are an immune system response to offending foods that can take up to two or three days to appear. These responses can be vague such as headaches, congestion, sinus, anxiety/depression and more.  Read more about the difference between food allergies and sensitivities here.

What Is Gluten?

According to the Celiac Disease Foundation, gluten is: “a general name for the proteins found in wheat (wheatberries, durum, emmer, semolina, spelt, farina, farro, graham, KAMUT® khorasan wheat and einkorn), rye, barley, and triticale – a cross between wheat and rye. Gluten helps foods maintain their shape, acting as a glue that holds food together. Gluten can be found in many types of foods, even ones that would not be expected.”

There are two main proteins in gluten. They are glutenin and gliadin and gliadin is the protein that is associated with the negative effects. Ten thousand years ago, wheat was not the version of wheat we have today. Emmer and Einkorn wheat were the crops of our ancestors while Triticum wheat is used today and is thousands of genes apart from original Einkorn wheat.triticum wheat

Triticum wheat has been bred to generate a greater yield, not a nutritionally sound product. Modern Triticum wheat of today can’t even survive in the wild without human support such as fertilizers and pest control.  Can you imagine eating a plant that can only survive at the hands of man-made chemicals?  Einkorn and Emmer wheat have survived the wild and pass on their nutrition powerhouse to those who eat it.

There have never been any safety studies involving animals or humans done on the hybridization of wheat and the new genetic strains created.  Plant geneticists were so intent on creating products to increase yield to satisfy the need to relieve world hunger, that it was assumed hybridizing wheat would result in a safe product. Because after all, wheat is wheat and wheat is a food product, right?

Gluten, What’s So Bad About It?

Gluten is the protein mixture of wheat.  It’s also in barley, rye, bulgur, Kamut, and triticale. Most Americans do not consume great quantities of rye, bulgar, Kamut and triticale, so for the purposes of this article wheat is the product I’m referring to when speaking about gluten. Barley, rye, bulgur, Kamut, and triticale have also not been hybridized to become the ultra glutinous products that wheat has become.

Gluten is what makes wheat ‘doughy’. That stretchable, rollable, elastic and twistable substance that rice flour, corn flour or any other flour cannot achieve.  Wheat is mostly carbohydrate and only ten to fifteen percent protein, and the majority of that protein (80%) is gluten. gluten dough

People who suffer from celiac disease are suffering from the most extreme form of gluten sensitivity.  It’s actually an autoimmune disease. During World War II, a pediatric gastroenterologist from the Netherlands noticed that mortality from celiac dropped about 40% during the war and then went back to pre-war mortality after the war was over.  At that time gluten was not known to be the reason. During the war, there was no wheat available and potato starch was used for making bread and the disease went away. Babies at the time were fed only bananas when presenting with celiac symptoms. After the war, the babies were put on an elimination diet of all grains and gluten. The babies responded favorably and thus the connection between gluten and autoimmune celiac disease.

Can there be other issues and autoimmune diseases stemming from gluten sensitivities? Most certainly.

Our journey begins with the digestive tract

Our intestines are a long, windy tube roughly 15 -20 feet long and covered by a single, yes a single layer of cells that is a barrier to keep the bacteria, toxins and undigested food out of our bloodstream. This single layer of cells, a mucous layer, allows microscopically sized nutrients like single blocks of sugars, proteins, and amino acids that have been broken down through digestion to pass through to the bloodstream to use for fuel and to supply our organs with what they need.  In order to pass through this single-celled mucosal barrier, the lining is permeable with very tight junctures so only the smallest of single blocks of nutrients can pass through.

This barrier should be impermeable to anything else.  But with celiac research, it was found that the barrier’s tight junctures or ‘doors were being opened for other substances like gluten to get through triggering an immediate immune system reaction.faulty-tight-junction

How Are These ‘Doors’ Opening?

Gluten is comprised of a substance called gliadin. Gliadin triggers the release of zonulin in the body.  Zonulin is the bodies trigger to save itself from an all-out infection that it cannot handle in the digestive system by opening up the ‘doors’ in the lining of the stomach to allow the infection to flow through to be fought by the bodies immune system.  What a wonderful last-ditch effort from Mother Nature to heal the body.

Unfortunately, it was the gliadin from the gluten that triggered the zonulin that opened the doors and there was no ‘threat’ to the body.  Now we have a gluten protein in the bloodstream that the body sees as a foreign invader. You do not need to have celiac disease for this response to happen.

The phenomenon of intestinal permeability caused by gluten due to the zonulin response is called ‘Leaky Gut’. When you have leaky gut, your symptoms can be all over the map like anxiety, depression, brain fog, fatigue, headaches and the list goes on and on. Over time these symptoms are associated with different autoimmune diseases like MS, Parkinsons, lupus etc. Some researchers have found when zonulin levels are kept in check, diabetes is kept at bay.

Experts believe that there need to be accurate tests for zonulin levels to prevent leaky gut syndrome and keep the ‘doors’ closed.

What Can You Do Today?

The first thing you must do is eliminate gluten for at least 4 weeks completely and see how you feel.  If you feel better, you need to continue complete elimination for 4 months to start healing your stomach.

Get your vitamin D levels checked. Increased intestinal permeability has been shown with low vitamin D levels. Aim for a range of 50 to 60 on a blood test. Increase your levels with a high-quality product

Drink organic bone broth to heal the lining of the stomach.

Avoid sugar. Sugar increases the bad bacteria leading to inflammation that opens the ‘doors’ of your intestine.

Take l-glutamine to heal your stomach lining for 3 months or longer depending on need.

In Conclusion

Gluten is a protein of wheat. Wheat has undergone major hybridization over the years yielding a wheat flour with high levels of gluten. For those with celiac disease, there is no tolerance of gluten and the body undergoes a major immune response that is damaging to the intestine.

The gliadin in gluten triggers the body to make zonulin which opens the ‘doors’ of the lining of the stomach allowing molecules of food and proteins into the bloodstream that should never be there. The body responds to these ‘threats’ as foreign invaders and can develop symptoms such as fatigue, headaches, depression, anxiety and more.  Over time autoimmune diseases can be diagnosed.

Take steps as outlined above to reduce your exposure to wheat and gluten and heal your stomach from the damaging effects of zonulin in the body in response to gluten.


Linda is a Functional Health Coach

14 Comments Add yours
  1. am in the process of eliminating all gluten products from diet. I am working with my doctor to see if this helps my overall feeling of feeling blah when it comes to my gut. I know of other people who have done the same with good results. I hope I am the same.

  2. Very knowledgeable stuff. I would have never known all of this if I had not seen this post. I was impressed at how the Einkorn & Emmer wheat can grow without the help of chemicals. We often eat way too much of things that are.

    1. So true Ronnie. Doesn’t it make you stop and think that we are eating a food that needs human intervention to survive? There is no evolution with these foods, they cannot ‘adapt’ to the environment and provide us with all the protections that evolution ensures.

  3. You know, Linda, I get an irresistible urge to eat bread every time I drive past a bakery that just finished baking bread. That aroma engulfs me. However, knowing what I know about wheat and from reading this article I see a correlation between my skin condition and possible symptoms from the bread I eat. I suffer from eczema on my legs but in the past, I never had this condition. I wonder if it is a threshold, or tolerance one reaches that causes symptoms to arise? I hate the thought of prescription medicine that will never cure the condition, only treat the symptoms.

    1. Kenneth, there is a good possibility that you are now sensitive to the gluten since eczema and other skin rashes and conditions are linked to it. Try avoiding it completely for 4 weeks and see what happens. I’d love to know how you feel and if your skin clears up. I too, love bread and have been a ‘carb addict’ all my life. lol. Within the past two years, I went off it for a month and then only eat it on the weekends occasionally now. The best thing I did for my health! If you’d like a handout with an explanation of how to eliminate gluten, let me know and I’ll send it to you.

  4. My mother has a gluten intolerance and has had to cut out gluten for the past 7 years. At first, I couldn’t imagine how much it must suck. After a few months of tasting some of her gluten free recipes, I couldn’t believe how tasty they were. I’m around 80% gluten free and I love it! Thanks for the informational article.

    1. Keiron, thank you for your comment. It’s true, once you cut it out you find substitutes and realize that it’s not so horrible after all. My daughter who is a carb nut in the form of bread was able to do it to and like you, is now 80 percent gluten-free. Bloating issues and congestion are gone.

  5. I would love to say that I will be able to eliminate gluten from my diet for 4 weeks. I’m not sure if I can do it, but at least now I have a target to consider. I am certain that removing gluten will help me since I have been diagnosed with arthritis and an elevated inflammation number. I have reduce the amount of sugar in my diet, not totally, but a great deal. Still, I’m sensing that gluten should be next. The information in this post is so helpful. Thanks for this very thorough post.

    1. You’re welcome, Claudette. Because of the addictive nature of gluten, it is overwhelming for people to consider removing it from their diet. Start slow. Remove it for one week. Then if you did it for one week, go for another. I think you’ll find some major improvements just in two weeks.

  6. Superb article and very good information about gluten and the issues related to it. I must say, this is one of the best article about this matter that I have ever read. Thank you so much for sharing with us, such an excellent article.

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